Abstract
Results of the hemostasis conduction in conditions of revascularization in 106 patients, оperated on for atherosclerotic affection of aorta and the main arteries of the lower extremities, were adduced. Syndrome of hypercoagulation of traumatic stage of surgical intervention in early postoperative period is developing due to thrombinemia on background of a fibrinolytic system depression. There was proved a necessity to impact on thrombin-fibrinous factor (factor ІІа) of hemocoagulant cascade by application of nonfractionized heparins immediately after conclusion of operative intervention with thromboprophylaxis prolongation, using low-molecular heparins (impact on Ха factor) in accordance to the branch standards.
MeSH terms
-
Anticoagulants / therapeutic use
-
Arteriosclerosis Obliterans / blood
-
Arteriosclerosis Obliterans / pathology
-
Arteriosclerosis Obliterans / surgery*
-
Factor Xa / metabolism
-
Femoral Artery / pathology
-
Femoral Artery / surgery*
-
Hemostasis / physiology
-
Heparin / therapeutic use*
-
Humans
-
Lower Extremity / blood supply
-
Lower Extremity / pathology
-
Lower Extremity / surgery
-
Neovascularization, Physiologic*
-
Postoperative Period
-
Prothrombin / antagonists & inhibitors
-
Prothrombin / metabolism
-
Thrombophilia / blood
-
Thrombophilia / pathology
-
Thrombophilia / prevention & control*
-
Vascular Surgical Procedures / instrumentation
-
Vascular Surgical Procedures / methods*
Substances
-
Anticoagulants
-
Prothrombin
-
Heparin
-
Factor Xa