Abstract
Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.
MeSH terms
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Acetaminophen / analogs & derivatives*
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Acetaminophen / metabolism
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Animals
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Antigens, Neoplasm / analysis*
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Antigens, Neoplasm / metabolism
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / metabolism
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Cell Line, Tumor
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Humans
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Mice
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Neoplasms / diagnosis*
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Neoplasms / metabolism
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Staining and Labeling / methods
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beta-Galactosidase / metabolism*
Substances
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Antigens, Neoplasm
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Biomarkers, Tumor
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Acetaminophen
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beta-Galactosidase