Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

Ann Rheum Dis. 2019 Mar;78(3):431-433. doi: 10.1136/annrheumdis-2018-214037. Epub 2018 Oct 3.

Coralie Briand^#¹, Marie-Louise Frémond^#^{1

2

3}, Didier Bessis⁴, Aurélia Carbasse⁵, Gillian I Rice⁶, Vincent Bondet^{7

8}, Darragh Duffy^{7

8

9}, Lucienne Chatenoud^{2

10

11}, Stéphane Blanche^{1

2}, Yanick J Crow^{2

3

12}, Bénédicte Neven^{13

2

14}

¹ Department of Paediatric Haematology-Immunology and Rheumatology, Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
² Paris Descartes University, Sorbonne-Paris-Cité, Paris, France.
³ Laboratory of Neurogenetics and Neuroinflammation, Institut Imagine, Paris, France.
⁴ Department of Dermatology, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
⁵ Paediatric Rheumatology Department, Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
⁶ Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
⁷ Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.
⁸ INSERM U1223, Institut Pasteur, Paris, France.
⁹ Centre for Translational Research, Institut Pasteur, Paris, France.
¹⁰ Laboratory of Immunology, Hôpital Necker-Enfants Malades, Paris, France.
¹¹ Institut Necker-Enfants Malades, CNRS UMR8253, INSERM UMR1151, Team "Immunoregulation and Immunopathology", Paris, France.
¹² Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
¹³ Department of Paediatric Haematology-Immunology and Rheumatology, Hôpital Necker-Enfants Malades, AP-HP, Paris, France [email protected].
¹⁴ INSERM UMR 1163, Laboratory of Immunogenetics of Paediatric Autoimmunity, Institut Imagine, Paris, France.

^# Contributed equally.

No abstract available

Keywords: inflammation; rehabilitation; treatment.

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