FLT3 pathway is a potential therapeutic target for PRC2-mutated T-cell acute lymphoblastic leukemia

Jingliao Zhang; Yingchi Zhang; Man Zhang; Chao Liu; Xiaoming Liu; Jie Yin; Peng Wu; Xiaojuan Chen; Wenyu Yang; Li Zhang; Ye Guo; Yao Zou; Yumei Chen; Youjia Cao; Tao Cheng; Xiaofan Zhu

doi:10.1182/blood-2018-04-845628

FLT3 pathway is a potential therapeutic target for PRC2-mutated T-cell acute lymphoblastic leukemia

Blood. 2018 Dec 6;132(23):2520-2524. doi: 10.1182/blood-2018-04-845628. Epub 2018 Oct 3.

Authors

Jingliao Zhang^{1

2

3}, Yingchi Zhang^{1

2

3}, Man Zhang⁴, Chao Liu^{1

2

3}, Xiaoming Liu^{1

2

3}, Jie Yin⁵, Peng Wu¹, Xiaojuan Chen^{1

2

3}, Wenyu Yang^{1

2

3}, Li Zhang^{1

2

3}, Ye Guo^{1

2

3}, Yao Zou^{1

2

3}, Yumei Chen^{1

2

3}, Youjia Cao⁴, Tao Cheng^{1

3}, Xiaofan Zhu^{1

2

3}

Affiliations

¹ State Key Laboratory of Experimental Hematology and.
² Division of Pediatric Blood Diseases Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
³ Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Beijing, China.
⁴ Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China; and.
⁵ Department of Cell Biology, Tianjin Medical University, Tianjin, China.

PMID: 30282797
DOI: 10.1182/blood-2018-04-845628

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Male
Mutation*
Polycomb Repressive Complex 2 / genetics*
Polycomb Repressive Complex 2 / metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / therapy
Signal Transduction / genetics*
fms-Like Tyrosine Kinase 3 / genetics*
fms-Like Tyrosine Kinase 3 / metabolism

Substances

Polycomb Repressive Complex 2
FLT3 protein, human
fms-Like Tyrosine Kinase 3