Abstract
Atopobium vaginae is an anaerobic Gram-positive bacterium recognized as a causative agent of bacterial vaginosis and associated with preterm delivery. Invasive infection and bacteremia have been rarely reported. We describe the case of a woman expecting her firstborn child who presented with a A. vaginae bacteremia during labor. Identification was performed using 16S rRNA gene sequencing. Both maternal and fetal outcomes were favorable due to the maternal treatment with amoxicillin-clavulanic acid. We identified three other cases in the literature with different fetal outcome. The genetic diversity of A. vaginae should be further explored in order to reveal potential strains with differential pathogenic potential.
Keywords:
16S rRNA gene; Atopobium vaginae; Bacteremia; MALDI TOF-MS; Pregnancy.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication types
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Case Reports
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Systematic Review
MeSH terms
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Actinobacteria / isolation & purification*
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Adult
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Amoxicillin-Potassium Clavulanate Combination / administration & dosage
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Anti-Bacterial Agents / administration & dosage
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Bacteremia / diagnosis*
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Bacteremia / microbiology
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Bacteremia / pathology*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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DNA, Ribosomal / chemistry
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DNA, Ribosomal / genetics
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Female
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Gram-Positive Bacterial Infections / diagnosis*
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Bacterial Infections / pathology*
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Humans
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Pregnancy
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Pregnancy Complications, Infectious / diagnosis*
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Pregnancy Complications, Infectious / microbiology
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Pregnancy Complications, Infectious / pathology*
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RNA, Ribosomal, 16S / genetics
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Sequence Analysis, DNA
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Treatment Outcome
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beta-Lactamase Inhibitors / administration & dosage
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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DNA, Ribosomal
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RNA, Ribosomal, 16S
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beta-Lactamase Inhibitors
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Amoxicillin-Potassium Clavulanate Combination