Recent advances in the applications of metabolomics in eye research

Liyan Chen; Yan Gao; Louis Zizhao Wang; Ning Cheung; Gavin S W Tan; Gemmy Chiu Ming Cheung; Roger W Beuerman; Tien Yin Wong; Eric Chun Yong Chan; Lei Zhou

doi:10.1016/j.aca.2018.01.060

Recent advances in the applications of metabolomics in eye research

Anal Chim Acta. 2018 Dec 11:1037:28-40. doi: 10.1016/j.aca.2018.01.060. Epub 2018 Feb 7.

Authors

Affiliations

¹ Singapore Eye Research Institute, Singapore.
² Singapore Eye Research Institute, Singapore; Department of Ophthalmology, National University Hospital, National University Health System, Singapore.
³ Singapore National Eye Centre, Singapore.
⁴ Singapore Eye Research Institute, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore.
⁵ Singapore Eye Research Institute, Singapore; Singapore National Eye Centre, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore.
⁶ Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore. Electronic address: [email protected].
⁷ Singapore Eye Research Institute, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Ophthalmology and Visual Science Academic Clinical Research Program, Duke-NUS Graduate Medical School, Singapore. Electronic address: [email protected].

PMID: 30292303
DOI: 10.1016/j.aca.2018.01.060

Abstract

Metabolomics, the identification and quantitation of metabolites in a system, have been applied to identify new biomarkers or elucidate disease mechanism. In this review, we discussed the application of metabolomics in several ocular diseases and recent developments in metabolomics regarding tear fluids analysis, data acquisition and processing.

Keywords: Eye disease; LC-MS/MS; Metabolite; Metabolomics; NMR.

Publication types

Review

MeSH terms

Animals
Eye / metabolism*
Humans
Metabolomics*