Objective: To prospectively explore the association between tea drinking and incidence of stroke of adults of Zhejiang province. Methods: After excluding participants with heart disease, stroke, cancer and diabetes at baseline study, 53 916 participants aged 30-79 years in the China Kadoorie Biobank (CKB) study from Tongxiang were included for final analysis. Cox regression model was used to estimate the hazard ratio (HR) for the association of tea drinking with incident stroke. Results: The main type of drinking tea was black tea (79.78%), followed by green tea (20.08%). Of the 53 916 participants, the proportion of participants who drank tea at least once per week was 31.27%. The corresponding proportions for men and women were 60.24% and 10.30%, respectively. Among 391 512 person-years of the follow-up program (median 7.26 years), a total of 1 487 men and 1 769 women were diagnosed with stroke. After adjusting for socio-demographic status, lifestyle, BMI, waist circumference, and systolic blood pressure, HR for incident stroke decreased with the increase of daily average tea consumption amount (P=0.000 6). Compared with participants who did not drink tea weekly, the HRs for incident stroke in those consuming tea 0.1-, 3.0- and ≥5.0 g/d were 0.93 (95%CI: 0.85-1.00), 0.88 (95%CI: 0.77-0.99) and 0.79 (95%CI: 0.69-0.89), respectively. The HRs for incident stroke in smokers and non-smokers who consumed tea ≥5.0 g/d were 0.71 (95%CI: 0.59-0.86) and 0.97 (95%CI: 0.77-1.21), respectively, compared with current smokers and non-smokers who did not drink tea weekly (P=0.040 0). The corresponding HRs for alcohol drinkers and non-drinkers were 0.96 (95%CI: 0.76-1.22) and 0.70 (95%CI: 0.58-0.84), respectively (P=0.040 0). The corresponding HRs for central obese persons and non-central obese persons were 0.60 (95%CI: 0.44-0.81) and 0.86 (95%CI: 0.73-1.01), respectively (P=0.040 0). Conclusion: Tea drinking had an effect on reducing the possibility of incident stroke, especially among those who were current smokers, non-alcohol drinkers and central obese.
目的： 探讨饮茶和成年人脑卒中发病的前瞻性关联。 方法： 使用"中国慢性病前瞻性研究"（CKB）浙江省桐乡市数据，剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后，纳入分析30~79岁53 916人。采用Cox比例风险模型计算脑卒中发病风险比（HR）。 结果： 桐乡居民最主要的饮茶品种为红茶（79.78%），其次是绿茶（20.08%）。调查对象中，每周饮茶者的比例为31.27%，其中男性和女性分别为60.24%和10.30%；调查对象累计随访391 512人年（平均随访7.26年）。随访期间，1 487例男性和1 769例女性被新诊断为脑卒中。在调整了人口社会学因素、生活方式、BMI、腰围和SBP等多种危险因素后，脑卒中发病风险随日均饮茶克数的增加而降低，趋势性检验差异有统计学意义（P=0.000 6）。与非每周饮茶者相比，日均饮茶0.1~、3.0~和≥5.0 g者脑卒中发病HR值（95%CI）分别为0.93（0.85~1.00）、0.88（0.77~0.99）和0.79（0.69~0.89）。与非每周饮茶者相比，日均饮茶≥5 g者脑卒中发病HR值（95%CI）在吸烟和不吸烟人群中分别为0.71（0.59~0.86）和0.97（0.77~1.21），差异有统计学意义（P=0.040 0），在不饮酒与饮酒的人群中分别为0.70（0.58~0.84）和0.96（0.76~1.22），差异有统计学意义（P=0.040 0），在中心性肥胖与非中心性肥胖人群中分别为0.60（0.44~0.81）和0.86（0.73~1.01），差异有统计学意义（P=0.040 0）。 结论： 饮茶可以降低脑卒中发病风险。与非每周饮茶者相比，饮茶的保护作用在吸烟者、不饮酒者以及中心性肥胖者中更明显。.
Keywords: Prospective study; Stroke; Tea drinking.