A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions

J Org Chem. 2018 Nov 2;83(21):13356-13362. doi: 10.1021/acs.joc.8b02149. Epub 2018 Oct 22.

Abstract

We report a facile and highly efficient method that copper-catalyzed intramolecular annulation to synthesize 3-hydroxy-1-indanones employing simple 2-ethynylbenzaldehyde as starting materials was achieved successfully. This protocol provided a simple synthetic approach to afford 3-hydroxy-1-indanones under mild conditions in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't