Abstract
This article describes a method for producing microRNA (miRNA)-enriched extracellular vesicles in large quantities. It enables in vivo delivery of specific miRNA for therapeutic applications.
Keywords:
extracellular vesicle; large-scale production; miRNA-133a-3p; miRNA-202-5p; microRNA.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Extracellular Vesicles / metabolism*
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Female
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Gene Transfer Techniques*
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HEK293 Cells
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Humans
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Mice
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Mice, Inbred C57BL
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MicroRNAs / administration & dosage*
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MicroRNAs / blood
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MicroRNAs / genetics
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MicroRNAs / isolation & purification*
Substances
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MIRN133 microRNA, human
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MIRN202 microRNA, human
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MicroRNAs