1 alpha,25-Dihydroxyvitamin D3 induces anchorage-independent growth and c-Ki-ras expression of BALB/3T3 and NIH/3T3 cells

Jpn J Cancer Res. 1987 Feb;78(2):99-102.

Abstract

1 alpha,25-Dihydroxyvitamin D3, a hormonally active form of vitamin D, induces anchorage-independent growth of BALB/3T3 A31-1-1 and NIH/3T3 cells with concomitant increase of their mRNA level of c-Ki-ras but not of c-Ha-ras or c-myc, through a receptor-mediated mechanism. Under the same conditions, 12-O-tetradecanoylphorbol-13-acetate did not induce anchorage-independent growth in these cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcitriol / pharmacology*
  • Cell Division / drug effects*
  • Cells, Cultured
  • Proto-Oncogenes*
  • RNA, Messenger / analysis
  • Receptors, Calcitriol
  • Receptors, Steroid / analysis
  • Tetradecanoylphorbol Acetate / pharmacology

Substances

  • RNA, Messenger
  • Receptors, Calcitriol
  • Receptors, Steroid
  • Calcitriol
  • Tetradecanoylphorbol Acetate