CSF3R/CD114 mediates infection-dependent transition to severe asthma

Hao Wang; Meaghan FitzPatrick; Nicholas J Wilson; Desiree Anthony; Patrick C Reading; Catherine Satzke; Eileen M Dunne; Paul V Licciardi; Huei Jiunn Seow; Kristy Nichol; Ian M Adcock; Kian Fan Chung; Gary P Anderson; Ross Vlahos; Peter Wark; Steven Bozinovski

doi:10.1016/j.jaci.2018.10.001

CSF3R/CD114 mediates infection-dependent transition to severe asthma

J Allergy Clin Immunol. 2019 Feb;143(2):785-788.e6. doi: 10.1016/j.jaci.2018.10.001. Epub 2018 Oct 9.

Authors

Hao Wang¹, Meaghan FitzPatrick², Nicholas J Wilson³, Desiree Anthony¹, Patrick C Reading⁴, Catherine Satzke⁵, Eileen M Dunne⁶, Paul V Licciardi⁶, Huei Jiunn Seow¹, Kristy Nichol⁷, Ian M Adcock⁸, Kian Fan Chung⁸, Gary P Anderson⁹, Ross Vlahos¹⁰, Peter Wark⁷, Steven Bozinovski¹¹

Affiliations

¹ School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia.
² Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia; CSL Limited, Parkville, Victoria, Australia.
³ CSL Limited, Parkville, Victoria, Australia.
⁴ WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
⁵ Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia; Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
⁶ Pneumococcal Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
⁷ Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and The University of Newcastle, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.
⁸ Airways Disease, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
⁹ Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia.
¹⁰ School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia.
¹¹ School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia; Department of Pharmacology & Therapeutics, Lung Health Research Centre, The University of Melbourne, Parkville, Victoria, Australia. Electronic address: [email protected].

PMID: 30312710
DOI: 10.1016/j.jaci.2018.10.001

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Animals
Antigens, Dermatophagoides / immunology
Asthma / complications
Asthma / metabolism*
Coinfection
Disease Models, Animal
Disease Progression
Female
Granulocyte Colony-Stimulating Factor / metabolism
Humans
Hypersensitivity / complications
Hypersensitivity / metabolism*
Influenza A virus / physiology*
Male
Mice
Mice, Inbred BALB C
Middle Aged
Neutrophils / metabolism*
Orthomyxoviridae Infections / complications
Orthomyxoviridae Infections / metabolism*
Pneumococcal Infections / complications
Pneumococcal Infections / metabolism*
Receptors, Colony-Stimulating Factor / metabolism*
Signal Transduction
Streptococcus pneumoniae / physiology*

Substances

Antigens, Dermatophagoides
CSF3R protein, human
Receptors, Colony-Stimulating Factor
Granulocyte Colony-Stimulating Factor