Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P < .001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.
Keywords: blindness/epidemiology; blindness/etiology; cerebral palsy/epidemiology; enterocolitis, necrotizing/epidemiology; enterocolitis, necrotizing/etiology; humans; incidence; infant; infant mortality; infant, extremely premature; infant, newborn; oximetry; oxygen/administration & dosage; oxygen/adverse effects; oxygen/blood; trial.
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