Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes

Leukemia. 2019 Feb;33(2):536-541. doi: 10.1038/s41375-018-0267-x. Epub 2018 Oct 12.

Abstract

  1. Activation of NF-κB signaling in mesenchymal cells is common in LR-MDS.

  2. Activation of NF-κB in mesenchymal cells leads to transcriptional overexpression of inflammatory factors including negative regulators of hematopoiesis.

  3. Activation of NF-κB attenuates HSPC numbers and function ex vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Case-Control Studies
  • Cells, Cultured
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Hematopoiesis*
  • Humans
  • Inflammation Mediators / metabolism*
  • Mesenchymal Stem Cells / immunology
  • Mesenchymal Stem Cells / metabolism
  • Mesenchymal Stem Cells / pathology*
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / immunology
  • Myelodysplastic Syndromes / metabolism
  • Myelodysplastic Syndromes / pathology*
  • NF-kappa B / genetics
  • NF-kappa B / metabolism*
  • Prognosis
  • Risk Factors

Substances

  • Biomarkers, Tumor
  • Inflammation Mediators
  • NF-kappa B