Management of Persistent Pruritus and Lichenoid Reaction Secondary to Nivolumab With Narrowband Ultraviolet B Phototherapy

Front Oncol. 2018 Sep 25:8:405. doi: 10.3389/fonc.2018.00405. eCollection 2018.

Abstract

Immune checkpoint inhibitors targeting the programmed cell death receptor 1 (PD-1) are increasingly used to treat several malignancies, with the most common adverse event being cutaneous toxicity. We report the case of a 68-years-old man with stage IV non-small cell lung cancer treated with nivolumab who developed a pruritic, lichenoid eruption refractory to treatment with topical or systemic steroids, who was started on narrow band ultraviolet B therapy which resolved the reaction.

Keywords: PD-1 inhibitor; dermatitis; immunotherapy; lichenoid; nivolumab; non-small cell lung cancer; phototherapy.

Publication types

  • Case Reports