Recommendations on the Use of Anti-CGRP Monoclonal Antibodies in Children and Adolescents

Headache. 2018 Nov;58(10):1658-1669. doi: 10.1111/head.13414. Epub 2018 Oct 15.

Authors

Christina L Szperka¹, Juliana VanderPluym², Serena L Orr³, Christopher B Oakley⁴, William Qubty⁵, Irene Patniyot⁶, Ana Marissa Lagman-Bartolome⁷, Cynthia Morris⁸, Jessica Gautreaux⁹, M Cristina Victorio¹⁰, Suzanne Hagler¹¹, Sona Narula¹, Meghan S Candee¹², Catalina Cleves-Bayon¹³, Rashmi Rao⁹, Robert H Fryer¹⁴, Alma R Bicknese¹⁵, Marcy Yonker¹⁶, Andrew D Hershey³, Scott W Powers³, Peter J Goadsby⁵, Amy A Gelfand⁵

Affiliations

¹ Division of Neurology, Children's Hospital of Philadelphia & Departments of Neurology & Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
² Mayo Clinic, Scottsdale, AZ, USA.
³ Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
⁴ John's Hopkins University, Baltimore, MD, USA.
⁵ University of California, San Francisco, CA, USA.
⁶ Baylor College of Medicine, Houston, TX, USA.
⁷ Women's College Hospital and Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
⁸ Saint Louis University School of Medicine, St. Louis, MO, USA.
⁹ Lousiana State University Health Science Center and Children's Hospital New Orleans, New Orleans, LA, USA.
¹⁰ Akron Children's Hospital, Akron, OH, USA.
¹¹ Nicklaus Children's Hospital, Miami, FL, USA.
¹² University of Utah, Primary Children's Hospital, Salt Lake City, UT, USA.
¹³ UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
¹⁴ Columbia University Medical Center, New York, NY, USA.
¹⁵ Feinberg School of Medicine at Northwestern University & Lurie Children's Hospital of Chicago, Chicago, IL, USA.
¹⁶ Children's Hospital Colorado, Aurora, CO, USA.

No abstract available

Keywords: adolescent; calcitonin gene-related peptide; migraine; monoclonal antibody; pediatric.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Animals
Antibodies, Monoclonal / administration & dosage
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal / pharmacokinetics
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized / administration & dosage
Antibodies, Monoclonal, Humanized / adverse effects
Antibodies, Monoclonal, Humanized / pharmacokinetics
Antibodies, Monoclonal, Humanized / therapeutic use
Body Size
Calcitonin Gene-Related Peptide / antagonists & inhibitors*
Calcitonin Gene-Related Peptide / immunology
Calcitonin Gene-Related Peptide / physiology
Calcitonin Gene-Related Peptide Receptor Antagonists / administration & dosage
Calcitonin Gene-Related Peptide Receptor Antagonists / adverse effects
Calcitonin Gene-Related Peptide Receptor Antagonists / immunology
Calcitonin Gene-Related Peptide Receptor Antagonists / therapeutic use*
Child
Clinical Trials as Topic
Cluster Headache / prevention & control
Contraindications, Drug
Dose-Response Relationship, Drug
Dose-Response Relationship, Immunologic
Female
Health Services Accessibility
Humans
Male
Migraine Disorders / prevention & control*
Patient Selection
Post-Traumatic Headache / prevention & control
Practice Guidelines as Topic*
Pregnancy
Pregnancy Complications / drug therapy
Receptors, Calcitonin Gene-Related Peptide / immunology*

Substances

Antibodies, Monoclonal
Antibodies, Monoclonal, Humanized
Calcitonin Gene-Related Peptide Receptor Antagonists
Receptors, Calcitonin Gene-Related Peptide
Calcitonin Gene-Related Peptide

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