Might Brushed Nasal Cells Be a Surrogate for CFTR Modulator Clinical Response?

Am J Respir Crit Care Med. 2019 Jan 1;199(1):123-126. doi: 10.1164/rccm.201808-1436LE.
No abstract available

Publication types

  • Letter
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines / therapeutic use
  • Benzodioxoles / therapeutic use
  • Biomarkers
  • Cystic Fibrosis / diagnosis*
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
  • Humans
  • Nasal Cavity / cytology*
  • Nasal Mucosa / metabolism
  • Treatment Outcome

Substances

  • Aminopyridines
  • Benzodioxoles
  • Biomarkers
  • CFTR protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • lumacaftor

Associated data

  • ClinicalTrials.gov/NCT02965326