[Radiation-induced lung toxicity predictors after stereotactic radiation therapy for non-small cell lung carcinoma stage I]

Cancer Radiother. 2018 Dec;22(8):826-838. doi: 10.1016/j.canrad.2017.12.007. Epub 2018 Oct 15.
[Article in French]

Abstract

In case of refusal or contraindication for surgical management of a stage I non-small cell lung carcinoma, the validated alternative therapy is stereotactic irradiation. This technique reaches an equivalent tumour control rate than surgery and significantly higher than conventional radiotherapy. One of the dreaded complications is radiation induced lung toxicity (radiation pneumonitis and lung fibrosis), especially when it is symptomatic, occurring in about 10 % of cases. This article is a literature review of this complication's predictive factors.

Keywords: Carcinome bronchopulmonaire non à petites cellules; Facteurs prédictifs; Fibrose pulmonaire; Non-small cell lung carcinoma; Pneumopathie radique; Predictors; Radiation fibrosis; Radiation induced lung toxicity; Radiation pneumonitis; Stereotactic radiotherapy; Stéréotaxie; Toxicité pulmonaire.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Biomarkers
  • Carcinoma, Non-Small-Cell Lung / drug therapy
  • Carcinoma, Non-Small-Cell Lung / radiotherapy*
  • Combined Modality Therapy
  • Comorbidity
  • Disease Susceptibility
  • Dose-Response Relationship, Radiation
  • Humans
  • Lung / diagnostic imaging
  • Lung / radiation effects*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / radiotherapy*
  • Mucin-1 / analysis
  • Neoplasm Proteins / analysis
  • Organs at Risk*
  • Radiation Pneumonitis / diagnosis
  • Radiation Pneumonitis / epidemiology
  • Radiation Pneumonitis / etiology*
  • Radiation Pneumonitis / prevention & control
  • Radiosurgery / adverse effects*
  • Respiration Disorders / complications
  • Respiration Disorders / epidemiology
  • Risk Factors
  • Treatment Outcome

Substances

  • Biomarkers
  • MUC1 protein, human
  • Mucin-1
  • Neoplasm Proteins