Obesity and type 2 diabetes: Also linked in therapeutic options

Endocrinol Diabetes Nutr (Engl Ed). 2019 Mar;66(3):140-149. doi: 10.1016/j.endinu.2018.08.003. Epub 2018 Oct 15.
[Article in English, Spanish]

Abstract

The prevalence of obesity has increased worldwide over the past decades. Obesity is associated with multiple comorbidities, such as type 2 diabetes, that generates a great impact on health and economy. Weight loss in these patients leads to glycemic control so it is a target to achieve. Lifestyle changes are not effective enough and recently other treatments have been developed such as bariatric/metabolic surgery, as well as drugs for type 2 diabetes and antiobesity drugs. The aim of this review is to compare the results in weight reduction and glycemic control of the different kinds of drugs with bariatric / metabolic surgery's results in type 2 diabetes.

Keywords: Antiobesity drugs; Bariatric surgery; Cirugía bariátrica; Cirugía metabólica; Clinical trials; Diabetes tipo 2; Ensayos clínicos; Fármacos para obesidad; Metabolic surgery; Obesidad; Obesity; Type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Anti-Obesity Agents / therapeutic use
  • Bariatric Surgery
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Comorbidity
  • Diabetes Mellitus, Type 2 / diet therapy
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / therapy*
  • Diet, Diabetic
  • Diet, Reducing
  • Drug Therapy, Combination
  • Forecasting
  • Humans
  • Hypoglycemic Agents / classification
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Multicenter Studies as Topic
  • Obesity / diet therapy
  • Obesity / epidemiology
  • Obesity / surgery
  • Obesity / therapy*
  • Weight Loss

Substances

  • Anti-Obesity Agents
  • Hypoglycemic Agents