Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine

Stephen Merrigan; Kamisha L Johnson-Davis

doi:10.1007/978-1-4939-8823-5_12

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method to Quantify Gabapentin and Pregabalin in Urine

Methods Mol Biol. 2019:1872:119-127. doi: 10.1007/978-1-4939-8823-5_12.

Authors

Stephen Merrigan^{1

2}, Kamisha L Johnson-Davis^{3

4}

Affiliations

¹ ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA.
² ARUP Laboratories, Salt Lake City, UT, USA.
³ ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA. [email protected].
⁴ Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT, USA. [email protected].

PMID: 30350285
DOI: 10.1007/978-1-4939-8823-5_12

Abstract

Gabapentin and pregabalin are anticonvulsant drugs that are also utilized for pain management. A mass spectrometry method was developed and validated to quantify gabapentin and pregabalin in urine to support testing for adherence.

Keywords: Anticonvulsants; LC-MS/MS; Mass spectrometry; Pain management; Urine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anticonvulsants / pharmacokinetics
Anticonvulsants / urine
Chromatography, Liquid*
Gabapentin / pharmacokinetics*
Gabapentin / urine
Humans
Pain Management
Pregabalin / pharmacokinetics*
Pregabalin / urine
Tandem Mass Spectrometry*

Substances

Anticonvulsants
Pregabalin
Gabapentin