Clearance of Treatment Refractory Adenoviremia via Adenovirus-specific Donor T-Cell Transfer During Aplasia After αβTCR-CD19-Depleted Stem Cell Transplantation

Clin Infect Dis. 2019 Apr 8;68(8):1406-1409. doi: 10.1093/cid/ciy820.

Abstract

Here, we report the case of severe adenoviremia in a 7-year-old boy with highly-resistant, acute leukemia. A combined approach of αβTCR-CD19-depleted stem cell transplantation, enabling immunosuppression-free post-transplant care, and early transfer of adenovirus-specific donor T cells during aplasia resulted in rapid and complete clearance of the treatment-refractory adenoviremia.

Keywords: adenoviremia; adenovirus; adenovirus-specific T cells; adoptive T-cell transfer; haploidentical stem cell transplantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenovirus Infections, Human / etiology
  • Adenovirus Infections, Human / therapy*
  • Antigens, CD19
  • Child
  • Combined Modality Therapy
  • Fatal Outcome
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / virology
  • T-Lymphocytes / transplantation*
  • T-Lymphocytes / virology*
  • Viremia / therapy*

Substances

  • Antigens, CD19