Emergence of a RET V804M Gatekeeper Mutation During Treatment With Vandetanib in RET-Rearranged NSCLC

J Thorac Oncol. 2018 Nov;13(11):e226-e227. doi: 10.1016/j.jtho.2018.06.021.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Mutation
  • Piperidines / pharmacology
  • Piperidines / therapeutic use*
  • Proto-Oncogene Proteins c-ret / genetics*
  • Quinazolines / pharmacology
  • Quinazolines / therapeutic use*

Substances

  • Piperidines
  • Quinazolines
  • Proto-Oncogene Proteins c-ret
  • RET protein, human
  • vandetanib