Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life

J Am Heart Assoc. 2018 Oct 16;7(20):e009778. doi: 10.1161/JAHA.118.009778.

Authors

Jennifer G Robinson¹, Kevin Jon Williams², Samuel Gidding³, Jan Borén⁴, Ira Tabas⁵, Edward A Fisher⁶, Chris Packard⁷, Michael Pencina⁸, Zahi A Fayad⁹, Venkatesh Mani⁹, Kerry Anne Rye¹⁰, Børge G Nordestgaard¹¹, Anne Tybjærg-Hansen¹¹, Pamela S Douglas¹², Stephen J Nicholls¹³, Neha Pagidipati¹², Allan Sniderman¹⁴

Affiliations

¹ 1 Department of Epidemiology and Medicine University of Iowa MS.
² 2 Lewis Katz School of Medicine, Temple University Philadelphia PA.
³ 3 Department of Pediatric Cardiology Nemours/Alfred I. duPont Hospital for Children DE.
⁴ 4 Department of Molecular and Clinical Medicine University of Gothenberg Sweden.
⁵ 5 Department of Medicine Columbia University Medical Center New York NY.
⁶ 6 Department of Cell Biology New York University School of Medicine New York NY.
⁷ 7 Department of Biochemistry University of Glasgow Scotland.
⁸ 8 Department of Biostatistics and Informatics Duke University Durham NC.
⁹ 9 Department of Radiology Mount Sinai School of Medicine New York NY.
¹⁰ 10 Department of Pathology University of New South Wales Sydney Australia.
¹¹ 11 Department of Clinical Medicine Copenhagen University Hospital Denmark.
¹² 13 Department of Cardiology Duke University Durham NC.
¹³ 12 Department of Cardiology University of Adelaide Australia.
¹⁴ 14 Department of Medicine University of Montreal Montreal Canada.

No abstract available

Keywords: apolipoprotein; primary prevention; randomized trial; regression.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Age Factors
Animals
Apolipoproteins B / metabolism*
Atherosclerosis / etiology
Atherosclerosis / prevention & control*
Clinical Trials as Topic
Cost of Illness
Diagnostic Imaging
Disease Eradication
Disease Models, Animal
Early Diagnosis
Humans
Hypolipidemic Agents
Plaque, Atherosclerotic / etiology
Plaque, Atherosclerotic / prevention & control
Practice Guidelines as Topic

Substances

Apolipoproteins B
Hypolipidemic Agents