Myelodysplastic syndrome with multilineage dysplasia evolving to acute myeloid leukemia: Noonan syndrome with c.218C>T mutation in PTPN11 gene

Pediatr Blood Cancer. 2019 Feb;66(2):e27527. doi: 10.1002/pbc.27527. Epub 2018 Oct 30.

Authors

Rathika Damodara Shenoy¹, Sunil Kumar Yeshvanth², Harsha Prasada L³, Vijaya Shenoy¹, Vikram Shetty⁴

Affiliations

¹ Department of Paediatrics, K.S. Hegde Medical Academy, NITTE (Deemed to be University), Karnataka, India.
² Department of Pathology, K.S. Hegde Medical Academy, NITTE (Deemed to be University), Karnataka, India.
³ Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education (Deemed to be University), Karnataka, India.
⁴ NITTE Meenakshi Institute of Craniofacial Surgery, NITTE (Deemed to be University), Karnataka, India.

PMID: 30378271
DOI: 10.1002/pbc.27527

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Child
Female
Humans
Leukemia, Myeloid, Acute / genetics*
Leukemia, Myeloid, Acute / pathology
Mutation
Myelodysplastic Syndromes / genetics*
Myelodysplastic Syndromes / pathology
Noonan Syndrome / genetics*
Noonan Syndrome / pathology
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / genetics*

Substances

PTPN11 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 11