A multi-parametric PET/MRI study of breast cancer: Evaluation of DCE-MRI pharmacokinetic models and correlation with diffusion and functional parameters

Marianna Inglese; Carlo Cavaliere; Serena Monti; Ernesto Forte; Mariarosaria Incoronato; Emanuele Nicolai; Marco Salvatore; Marco Aiello

doi:10.1002/nbm.4026

A multi-parametric PET/MRI study of breast cancer: Evaluation of DCE-MRI pharmacokinetic models and correlation with diffusion and functional parameters

NMR Biomed. 2019 Jan;32(1):e4026. doi: 10.1002/nbm.4026. Epub 2018 Oct 31.

Authors

Marianna Inglese^{1

2}, Carlo Cavaliere¹, Serena Monti¹, Ernesto Forte¹, Mariarosaria Incoronato¹, Emanuele Nicolai¹, Marco Salvatore¹, Marco Aiello¹

Affiliations

¹ IRCCS SDN, Naples, Italy.
² Department of Computer, Control and Management Engineering Antonio Ruberti, University of Rome 'La Sapienza', Italy.

PMID: 30379384
DOI: 10.1002/nbm.4026

Abstract

46 patients with histologically confirmed breast cancer were enrolled and imaged with a 3T hybrid PET/MRI system, at staging. Diffusion, functional and perfusion parameters (measured by Tofts and shutter speed models) were compared. Results showed a good correlation between pharmacokinetic parameters and the SUV.

Keywords: DCE-MRI; PET/MR; Tofts model; breast cancer; diffusion imaging; pharmacokinetic models; shutter speed model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Breast Neoplasms / diagnostic imaging*
Contrast Media / chemistry*
Contrast Media / pharmacokinetics
Diffusion
Female
Humans
Magnetic Resonance Imaging*
Middle Aged
Positron-Emission Tomography*
Statistics, Nonparametric

Substances

Contrast Media