The Human Papillomavirus as a Common Pathogen in Oropharyngeal, Anal and Cervical Cancers

S Otter; S Whitaker; J Chatterjee; A Stewart

doi:10.1016/j.clon.2018.10.004

The Human Papillomavirus as a Common Pathogen in Oropharyngeal, Anal and Cervical Cancers

Clin Oncol (R Coll Radiol). 2019 Feb;31(2):81-90. doi: 10.1016/j.clon.2018.10.004. Epub 2018 Oct 29.

Authors

S Otter¹, S Whitaker², J Chatterjee³, A Stewart³

Affiliations

¹ St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, UK; University of Surrey, Guildford, UK. Electronic address: [email protected].
² St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, UK.
³ St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, UK; University of Surrey, Guildford, UK.

PMID: 30385006
DOI: 10.1016/j.clon.2018.10.004

Abstract

The burden of human papillomavirus (HPV)-related cancers worldwide is significant. Although the incidence of cervical cancer is decreasing due to cervical screening programmes, the incidences of oropharyngeal, anal and vulval cancers are increasing. The introduction of HPV vaccination programmes in many countries has had an impact on HPV infection rates but due to the time-lag from initial HPV infection to the development of invasive carcinoma, the impact on the incidence of HPV-related cancer will take more time to become evident. This review explores the common aspects of HPV-related cancers and how they differ from their HPV-negative counterparts, both clinically and molecularly. It also covers the implications this has on future treatment strategies, including the possible role of immunotherapy.

Keywords: Anal cancer; cervical cancer; human papillomavirus; oropharyngeal cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anus Neoplasms / virology*
Early Detection of Cancer / methods*
Female
Humans
Male
Oropharyngeal Neoplasms / virology*
Papillomaviridae / pathogenicity*
Papillomavirus Infections / virology*
Uterine Cervical Neoplasms / virology*