Revisiting the Warburg Effect: Some Tumors Hold Their Breath

Sydney M Sanderson; Jason W Locasale

doi:10.1016/j.cmet.2018.10.011

Revisiting the Warburg Effect: Some Tumors Hold Their Breath

Cell Metab. 2018 Nov 6;28(5):669-670. doi: 10.1016/j.cmet.2018.10.011.

Authors

Sydney M Sanderson¹, Jason W Locasale²

Affiliations

¹ Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
² Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: [email protected].

Abstract

Studies have shown that tumors commonly exhibit normal or enhanced respiration in addition to glycolytic metabolism. In this issue, Courtney et al. (2018) report a reduction in mitochondrial function in kidney cancer patients and thus a classic "Warburg Effect" that further illustrates the heterogeneity of human cancer metabolism.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carcinoma, Renal Cell*
Glucose*
Glycolysis
Humans
Isotopes
Mitochondria

Substances

Isotopes
Glucose

Abstract

Publication types

MeSH terms

Substances

Grants and funding