Abstract
Issues concerning contraception, fertility, and pregnancy usually arise during a typical lupus patient's disease course. Pregnancy superimposed on established lupus may alter the course of the disease, and, conversely, lupus may affect the natural history of pregnancy. Two recently described autoantibody markers, anti-SSA (Ro) and anticardiolipin, have provided new insights concerning fetal risks in these patients. Furthermore, they should lead to improved understanding of mechanisms of tissue injury and to new ideas about therapeutic interventions and/or prevention of pregnancy complications.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adrenal Cortex Hormones / therapeutic use
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Autoantibodies / analysis
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Autoantigens / immunology
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Breast Feeding
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Family Planning Services
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Female
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Humans
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Lupus Erythematosus, Systemic* / drug therapy
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Lupus Erythematosus, Systemic* / physiopathology
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Lupus Erythematosus, Systemic* / therapy
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Lupus Nephritis / physiopathology
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Pregnancy / physiology
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Pregnancy Complications*
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Pregnancy Outcome
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RNA, Small Cytoplasmic*
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Ribonucleoproteins*
Substances
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Adrenal Cortex Hormones
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Autoantibodies
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Autoantigens
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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SS-A antigen