Zinc(II)-Dipicolylamine Coordination Nanotheranostics: Toward Synergistic Nanomedicine by Combined Photo/Gene Therapy

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):269-272. doi: 10.1002/anie.201812482. Epub 2018 Dec 5.

Abstract

We report the rational design of coordination-driven self-assembly metal-organic nanostructures for multifunctional nanotheranostics. Zinc(II) coordination-based nano-formulations capable of loading indocyanine green (ICG) and therapeutic genes were prepared to achieve a fluorescence/photoacoustic imaging-guided combination photo/gene therapy strategy. We showed the enhanced theranostic capability of zinc(II)-dipicolylamine-assisted assembly of ICG, as well as simultaneous targeted gene delivery in an experimental mouse model of cancer. Such a co-assembly strategy provides a facile way to achieve combined therapeutic functions for personalized nanomedicine.

Keywords: ZnII-dipicolylamine; gene therapy; indocyanine green; metal-organic nanostructures; phototherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Therapy / methods*
  • Humans
  • Nanomedicine / methods*
  • Phototherapy / methods*
  • Zinc / chemistry*

Substances

  • Zinc