Monocyte/HDL Ratio and Lymphocyte/Monocyte Ratio in Patients with Pseudoexfoliation Syndrome

Ocul Immunol Inflamm. 2020;28(1):142-146. doi: 10.1080/09273948.2018.1545913. Epub 2018 Nov 13.

Abstract

Purpose: To evaluate the association between monocyte count/high-density lipoprotein (HDL) ratio (MHR) and lymphocyte count/monocyte count ratio (LMR) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).Materials and Methods: A total of 63 participants included in the study. Participants were divided into three groups. Twenty-one patients with PEXS regarded as group 1, 21 patients with PEXG regarded as group 2 and 21 participants without PEXS or PEXG regarded as the control group. Blood parameters were accessed from file records and database retrospectively.Results: The mean MHRs were significantly higher in group 1 and group 2 (p = 0.003, p = 0.036) than the control group, whereas there was no difference between group 1 and group 2 (p = 0.686). The mean LMRs were lower in group 1 and group 2 than the control group but the difference was insignificant (p = 0.232).Conclusion: We found that there is an association between higher MHR and lower LMR with PEXS.

Keywords: LMR; MHR; lymphocyte/monocyte ratio; monocyte/HDL ratio; pseudoexfoliation.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Exfoliation Syndrome / blood*
  • Exfoliation Syndrome / diagnosis
  • Female
  • Glaucoma, Open-Angle / blood*
  • Glaucoma, Open-Angle / diagnosis
  • Humans
  • Leukocyte Count
  • Lipoproteins, HDL / blood*
  • Lymphocytes / metabolism*
  • Male
  • Middle Aged
  • Monocytes / metabolism*
  • ROC Curve
  • Retrospective Studies

Substances

  • Biomarkers
  • Lipoproteins, HDL