Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay

Nat Prod Commun. 2017 Feb;12(2):261-262.

Abstract

Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopusjaponicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds I and 2 were shown to have moderate antiangiogenesis activity when tested using-the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / chemistry
  • 4-Butyrolactone / isolation & purification*
  • Angiogenesis Inhibitors / chemistry
  • Angiogenesis Inhibitors / isolation & purification*
  • Animals
  • Aspergillus / chemistry*
  • Stichopus / microbiology*
  • Zebrafish

Substances

  • Angiogenesis Inhibitors
  • terrelactone A
  • butyrolactone I
  • 4-Butyrolactone