Abstract
The unexpected transmission of donor-derived infection through organ transplantation is a rare event with current donor screening practices. In this case report we describe a probable donor-derived transmission of Herpes Simplex Virus (HSV)-2 via deceased donor kidney transplantation resulting in HSV hepatitis in the recipient. This manifested as acute liver failure which resolved with appropriate anti-viral therapy. Following recovery from the acute liver insult, the patient developed fibrotic liver morphology and portal hypertension, an unusual departure from the typical course.
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
MeSH terms
-
Acyclovir / therapeutic use
-
Adult
-
Allografts / virology
-
Antiviral Agents / therapeutic use
-
Biopsy
-
Female
-
Hepatitis, Viral, Human / diagnosis
-
Hepatitis, Viral, Human / pathology
-
Hepatitis, Viral, Human / transmission
-
Hepatitis, Viral, Human / virology*
-
Herpes Simplex / diagnosis
-
Herpes Simplex / pathology
-
Herpes Simplex / transmission
-
Herpes Simplex / virology*
-
Herpesvirus 2, Human / isolation & purification
-
Humans
-
Hypertension, Portal / etiology*
-
Hypertension, Portal / pathology
-
Hypertension, Portal / therapy
-
Kidney / virology
-
Kidney Transplantation / adverse effects*
-
Liver / pathology
-
Liver / virology
-
Liver Cirrhosis / complications
-
Liver Cirrhosis / pathology
-
Liver Cirrhosis / therapy
-
Liver Cirrhosis / virology*
-
Liver Failure, Acute / etiology*
-
Liver Failure, Acute / pathology
-
Liver Failure, Acute / therapy
-
Treatment Outcome
Substances
-
Antiviral Agents
-
Acyclovir