Development of paper substrate for paper spray MS in high-sensitivity analysis of biological samples

Paper spray (PS) has demonstrated a promising future for direct mass spectrometric analysis. In the process of PS, paper substrate has been demonstrated as a crucial factor in determining the final performance of PS-MS, and therefore much attention is paid to modification of paper substrate. In this review, we systematically introduce the development of paper substrate for PS. Various commercial and modified papers are comprehensively reviewed, and much effort is focused on some physical and chemical approaches for modification of paper substrate. The application of modified paper substrates to biological sample analyses is discussed. The future promising directions of paper substrate for PS are highlighted.