Fibrin sealant agents: clinical application of TachoSil® in abdominal surgery. Six years experience in an emergency surgery department and review of the literature

G Chir. 2018 Sep-Oct;34(5):326-330.

Abstract

Background: The success of every surgical procedure depends on an appropriate hemostatis. Topical haemostatic agents, like fibrin sealants, are an option for providing haemostasis and may be particularly useful for complex injuries.

Aim: The aim of the study is to evaluate the use of TachoSil® in abdominal surgery and its benefits to prevent bleedings, and to establish its fields of use.

Methods: A retrospective observational study was performed on 308 patients underwent to emergency surgery with TachoSil®'s application into our department between January 2012 and March 2018.

Results: After the application of the hemostatic device there have been no haemorrhagic complications that have needed a second surgical intervention. Most frequently use of TachoSil® was in the gallbladder bed after cholecystectomy for an acute cholecystitis.

Conclusions: Our experience, supported by other reports in the literature, suggests the use of TachoSil® may provide an effective option in helping to control bleedings.

Publication types

  • Review

MeSH terms

  • Abdomen / surgery*
  • Diagnosis-Related Groups
  • Drug Combinations
  • Emergencies
  • Emergency Service, Hospital
  • Female
  • Fibrin Tissue Adhesive / administration & dosage
  • Fibrin Tissue Adhesive / therapeutic use*
  • Fibrinogen / administration & dosage
  • Fibrinogen / therapeutic use*
  • Hemostasis, Surgical / methods*
  • Hemostatics / administration & dosage
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Retrospective Studies
  • Surgery Department, Hospital
  • Thrombin / administration & dosage
  • Thrombin / therapeutic use*

Substances

  • Drug Combinations
  • Fibrin Tissue Adhesive
  • Hemostatics
  • TachoSil
  • Fibrinogen
  • Thrombin