1 Department of Otolaryngology-Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka Translational Research Center for Medical Innovation, Foundation for Biomedical Research and Innovation at Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Medical Research Institute, Kitano Hospital, Osaka, Japan Regulatory Science Group, Divsion of Medical Innovation, Translational Research Center for Medical Innovation Foundation for Biomedical Research and Innovation at Kobe, Japan Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto Prefectural Medical College, Kyoto, Japan.