Radiation-induced lung toxicity in mice irradiated in a strong magnetic field

PLoS One. 2018 Nov 16;13(11):e0205803. doi: 10.1371/journal.pone.0205803. eCollection 2018.

Abstract

Strong magnetic fields affect radiation dose deposition in MRI-guided radiation therapy systems, particularly at interfaces between tissues of differing densities such as those in the thorax. In this study, we evaluated the impact of a 1.5 T magnetic field on radiation-induced lung damage in C57L/J mice. We irradiated 140 mice to the whole thorax with parallel-opposed Co-60 beams to doses of 0, 9.0, 10.0, 10.5, 11.0, 12.0, or 13.0 Gy (20 mice per dose group). Ten mice per dose group were irradiated while a 1.5 T magnetic field was applied transverse to the radiation beam and ten mice were irradiated with the magnetic field set to 0 T. We compared survival and noninvasive assays of radiation-induced lung damage, namely respiratory rate and metrics derived from thoracic cone-beam CTs, between the two sets of mice. We report two main results. First, the presence of a transverse 1.5 T field during irradiation had no impact on survival of C57L/J mice. Second, there was a small but statistically significant effect on noninvasive assays of radiation-induced lung damage. These results provide critical safety data for the clinical introduction of MRI-guided radiation therapy systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electromagnetic Fields / adverse effects
  • Humans
  • Lung / physiopathology
  • Lung / radiation effects*
  • Magnetic Resonance Imaging / adverse effects
  • Mice
  • Radiation Dosage
  • Radiation Injuries, Experimental / etiology
  • Radiation Injuries, Experimental / physiopathology*
  • Radiotherapy, Image-Guided / adverse effects*
  • Thorax / physiopathology*
  • Thorax / radiation effects