ANCA Renal Risk Score: is prediction of end-stage renal disease at baseline possible?

Andreas Kronbichler; David R W Jayne

doi:10.1016/j.kint.2018.10.001

ANCA Renal Risk Score: is prediction of end-stage renal disease at baseline possible?

Kidney Int. 2018 Dec;94(6):1045-1047. doi: 10.1016/j.kint.2018.10.001.

Authors

Andreas Kronbichler¹, David R W Jayne²

Affiliations

¹ Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.
² Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: [email protected].

PMID: 30466561
DOI: 10.1016/j.kint.2018.10.001

Abstract

Despite improved overall prognosis of patients with ANCA-associated vasculitis (AAV), those presenting with impaired renal function remain at risk of developing end-stage renal disease (ESRD). In addition to its role in diagnosis, renal histology provides prognostic information that has permitted definition of subgroups with differing risks of ESRD. In this issue, Brix et al. have developed and validated a risk score to predict the probability of ESRD. Against a background of outcome prediction in AAV, this commentary assesses different approaches to histologic risk and to what extent they assist with decisions on patient management.

Publication types

Comment

MeSH terms

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*
Antibodies, Antineutrophil Cytoplasmic
Glomerulonephritis*
Humans
Kidney
Kidney Failure, Chronic*

Substances

Antibodies, Antineutrophil Cytoplasmic