Abstract
The purpose of this paper is to discuss briefly the mechanism of aminoglycosides nephrotoxicity. This kind of antibiotic seems to act preferentially on the phospholipid metabolism of the proximal tubular cell. A lysosomal enzyme, N-acetyl-beta-D-glucosaminidase, could be of interest in assessing this renal interference.
MeSH terms
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Acetylglucosaminidase / urine*
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Aging / urine
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Aminoglycosides
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Animals
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Anti-Bacterial Agents / adverse effects*
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Anti-Bacterial Agents / toxicity
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Clinical Enzyme Tests*
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Hexosaminidases / urine*
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Humans
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Infant, Newborn / urine*
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Kidney Diseases / chemically induced*
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Kidney Diseases / enzymology
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Kidney Diseases / pathology
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Lysosomes / drug effects
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Hexosaminidases
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Acetylglucosaminidase