Exons of Leukemia Suppressor Genes: Creative Assembly Required

Mukta Asnani; Andrei Thomas-Tikhonenko

doi:10.1016/j.trecan.2018.10.005

Exons of Leukemia Suppressor Genes: Creative Assembly Required

Trends Cancer. 2018 Dec;4(12):796-798. doi: 10.1016/j.trecan.2018.10.005. Epub 2018 Oct 28.

Authors

Mukta Asnani¹, Andrei Thomas-Tikhonenko²

Affiliations

¹ Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
² Division of Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: [email protected].

Abstract

Alternative splicing (AS) has many important roles in the pathogenesis of leukemia. Recent papers suggest that one of its key aspects is exclusion of 3'-terminal exons in favor of premature termination using intronic polyadenylation signals. This process generates leukemia suppressor isoforms with truncated C termini and acting in loss-of-function or dominant-negative manners.

Keywords: RNA processing; alternative splicing; cancer; intronic polyadenylation; leukemia; protein diversity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Alternative Splicing / genetics
Exons / genetics*
Gene Expression Regulation, Leukemic*
Genes, Tumor Suppressor*
Humans
Leukemia / genetics*
Loss of Function Mutation
Polyadenylation / genetics
Protein Isoforms / genetics
RNA, Messenger / genetics
RNA, Messenger / metabolism

Substances

Protein Isoforms
RNA, Messenger

Grants and funding

U01 CA232563/CA/NCI NIH HHS/United States