Sonic Hedgehog Signaling is Blue: Insights from the Patched Mutant Mice

Daniel J Merk; Rosalind A Segal

doi:10.1016/j.tins.2018.08.013

Sonic Hedgehog Signaling is Blue: Insights from the Patched Mutant Mice

Trends Neurosci. 2018 Dec;41(12):870-872. doi: 10.1016/j.tins.2018.08.013.

Authors

Daniel J Merk¹, Rosalind A Segal²

Affiliations

¹ Departments of Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
² Departments of Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].

PMID: 30471664
DOI: 10.1016/j.tins.2018.08.013

Abstract

The Hedgehog (Hh) pathway is a highly conserved signaling system regulating a range of developmental processes. A 1997 paper by Goodrich and colleagues provided major contributions to understanding the Hh pathway by mutating the gene encoding the Hh receptor, Patched, and thereby developing a mouse model for a human cancer predisposition syndrome, known as Gorlin syndrome. These studies provided one of the first genetically engineered mouse models for brain tumors.

Keywords: Gorlin syndrome; Patched; Shh; basal cell carcinoma; medulloblastoma; pediatric brain tumor.

Publication types

Review

MeSH terms

Animals
Hedgehog Proteins / physiology*
Mice
Mutation*
Neurogenesis / genetics
Neurogenesis / physiology*
Patched-1 Receptor / genetics*

Substances

Hedgehog Proteins
Patched-1 Receptor
Shh protein, mouse