Pediatric silent corticotroph pituitary adenoma and role for proton therapy: case report

J Neurosurg Pediatr. 2019 Feb 1;23(2):214-218. doi: 10.3171/2018.9.PEDS18107. Epub 2018 Nov 16.

Abstract

Tumors involving the sella are commonly craniopharyngiomas, optic pathway gliomas, or pituitary adenomas. Functioning adenomas are expected, with prolactinomas topping the differential. The authors present the case of a silent corticotroph adenoma, which has not been described in the pediatric population, and they detail the use of proton therapy, which is also novel.

Keywords: ACTH = adrenocorticotrophic hormone; CTV = clinical target volume; EVD = external ventricular drain; FSH = follicle-stimulating hormone; GH = growth hormone; IGF-1 = insulin-like growth factor–1; NFA = nonfunctioning adenoma; RT = radiation therapy; SCA = silent corticotroph adenoma; brain tumor; pediatric; pituitary adenoma; pituitary surgery; proton therapy.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / diagnostic imaging
  • Adenoma / pathology
  • Adenoma / radiotherapy*
  • Adenoma / surgery
  • Adolescent
  • Corticotrophs* / pathology
  • Humans
  • Hydrocephalus / diagnostic imaging
  • Hydrocephalus / etiology
  • Hyponatremia / etiology
  • Male
  • Pituitary Neoplasms / diagnostic imaging
  • Pituitary Neoplasms / pathology
  • Pituitary Neoplasms / radiotherapy*
  • Pituitary Neoplasms / surgery
  • Postoperative Complications
  • Proton Therapy*
  • Tumor Burden