Abstract
Iridium complexes were used as a mitochondria-targeting agent to modify the surface of a photothermogenic nanozyme Fe3O4 nanoparticles (Ir@Fe3O4 NPs). Upon NIR irradiation, Ir@Fe3O4 NPs increase the localized temperature to 42 °C which accelerates the catalysis of ˙OH production from H2O2 resulting in excellent mild photothermal therapy.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / radiation effects
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Antineoplastic Agents / therapeutic use*
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Antineoplastic Agents / toxicity
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Coordination Complexes / chemical synthesis
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Coordination Complexes / radiation effects
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Coordination Complexes / therapeutic use*
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Coordination Complexes / toxicity
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Female
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HeLa Cells
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Heating
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Humans
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Hydrogen Peroxide / chemistry
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Hydroxyl Radical / chemical synthesis
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Hydroxyl Radical / therapeutic use
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Infrared Rays
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Iridium / chemistry
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Magnetite Nanoparticles / chemistry
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Magnetite Nanoparticles / radiation effects
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Magnetite Nanoparticles / therapeutic use*
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Magnetite Nanoparticles / toxicity
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Mice, Inbred BALB C
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Mitochondria / metabolism*
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Photochemotherapy / methods*
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Temperature
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Uterine Cervical Neoplasms / drug therapy*
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Coordination Complexes
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Magnetite Nanoparticles
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Hydroxyl Radical
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Iridium
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Hydrogen Peroxide