A mitochondria-targeting photothermogenic nanozyme for MRI-guided mild photothermal therapy

Chem Commun (Camb). 2018 Dec 13;54(100):14108-14111. doi: 10.1039/c8cc08570f.

Abstract

Iridium complexes were used as a mitochondria-targeting agent to modify the surface of a photothermogenic nanozyme Fe3O4 nanoparticles (Ir@Fe3O4 NPs). Upon NIR irradiation, Ir@Fe3O4 NPs increase the localized temperature to 42 °C which accelerates the catalysis of ˙OH production from H2O2 resulting in excellent mild photothermal therapy.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / radiation effects
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Agents / toxicity
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / radiation effects
  • Coordination Complexes / therapeutic use*
  • Coordination Complexes / toxicity
  • Female
  • HeLa Cells
  • Heating
  • Humans
  • Hydrogen Peroxide / chemistry
  • Hydroxyl Radical / chemical synthesis
  • Hydroxyl Radical / therapeutic use
  • Infrared Rays
  • Iridium / chemistry
  • Magnetite Nanoparticles / chemistry
  • Magnetite Nanoparticles / radiation effects
  • Magnetite Nanoparticles / therapeutic use*
  • Magnetite Nanoparticles / toxicity
  • Mice, Inbred BALB C
  • Mitochondria / metabolism*
  • Photochemotherapy / methods*
  • Temperature
  • Uterine Cervical Neoplasms / drug therapy*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Magnetite Nanoparticles
  • Hydroxyl Radical
  • Iridium
  • Hydrogen Peroxide