In Vitro Activity of Omadacycline against Chlamydia pneumoniae

Stephan A Kohlhoff; Natalia Huerta; Margaret R Hammerschlag

doi:10.1128/AAC.01907-18

In Vitro Activity of Omadacycline against Chlamydia pneumoniae

Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01907-18. doi: 10.1128/AAC.01907-18. Print 2019 Feb.

Authors

Stephan A Kohlhoff¹, Natalia Huerta², Margaret R Hammerschlag²

Affiliations

¹ Department of Pediatrics, Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA [email protected].
² Department of Pediatrics, Division of Pediatric Infectious Diseases, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

Abstract

The in vitro activities of omadacycline, azithromycin, doxycycline, moxifloxacin, and levofloxacin were tested against 15 isolates of Chlamydia pneumoniae The minimum inhibitory concentration at which 90% of the isolates of C. pneumoniae were inhibited by omadacycline was 0.25 μg/ml (range, 0.03 to 0.5 μg/ml).

Keywords: Chlamydia pneumoniae; omadacycline; tetracyclines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Azithromycin / pharmacology
Cell Line
Chlamydial Pneumonia / drug therapy
Chlamydial Pneumonia / microbiology
Chlamydophila pneumoniae / drug effects*
Chlamydophila pneumoniae / isolation & purification
Doxycycline / pharmacology
Humans
Levofloxacin / pharmacology
Microbial Sensitivity Tests
Moxifloxacin / pharmacology
Tetracyclines / pharmacology*

Substances

Anti-Bacterial Agents
Tetracyclines
omadacycline
Levofloxacin
Azithromycin
Doxycycline
Moxifloxacin