Cell Cycle: Abrogating Interphase/M Phase Bistability

Curr Biol. 2018 Dec 3;28(23):R1342-R1345. doi: 10.1016/j.cub.2018.10.011.

Abstract

A new study reports the ability to generate cells caught in a 'no-man's land' between interphase and M phase by simultaneously disrupting feedback loops controlling the activities of the main mitotic driver Cdk1-cyclin B and its counteracting phosphatase PP2A-B55.

Publication types

  • Comment

MeSH terms

  • Animals
  • CDC2 Protein Kinase
  • Interphase
  • Mitosis*
  • Phosphorylation
  • Protein Phosphatase 2*

Substances

  • CDC2 Protein Kinase
  • Protein Phosphatase 2