On your marks, get SET(D1A): the race to protect stalled replication forks

Shabana Begum; Amalia Goula; Rachel Bayley; Martin R Higgs

doi:10.1080/23723556.2018.1511209

On your marks, get SET(D1A): the race to protect stalled replication forks

Mol Cell Oncol. 2018 Oct 11;5(6):e1511209. doi: 10.1080/23723556.2018.1511209. eCollection 2018.

Authors

Shabana Begum¹, Amalia Goula¹, Rachel Bayley¹, Martin R Higgs¹

Affiliation

¹ Lysine Methylation and DNA Damage Laboratory, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.

Abstract

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA complementation group D2), a crucial step in maintaining genome integrity with important implications in chemo-sensitivity.

Keywords: CHD4; Chemoresistance; FANCD2; Genome stability; SETD1A; replication stress.

Grants and funding

MR/P009085/1/MRC_/Medical Research Council/United Kingdom