6p+ and 9q- in two chromosomally distinct clones occurring in a case of myelodysplastic syndrome evolving to acute nonlymphocytic leukemia

A Ringressi; C Mecucci; A Grossi; P A Bernabei; P R Ferrini; H Van den Berghe

doi:10.1016/0165-4608(88)90243-9

6p+ and 9q- in two chromosomally distinct clones occurring in a case of myelodysplastic syndrome evolving to acute nonlymphocytic leukemia

Cancer Genet Cytogenet. 1988 Oct 15;35(2):213-21. doi: 10.1016/0165-4608(88)90243-9.

Authors

A Ringressi¹, C Mecucci, A Grossi, P A Bernabei, P R Ferrini, H Van den Berghe

Affiliation

¹ Department of Hematology, University of Florence, Italy.

PMID: 3052797
DOI: 10.1016/0165-4608(88)90243-9

Abstract

Different and unrelated chromosome changes were found to occur in a patient with a myelodysplastic syndrome with rapid evolution to acute nonlymphocytic leukemia. A 6p anomaly was found during the chronic phase and a del(9q) characterized the cells in the leukemic phase. Deletions with a breakpoint in 9q31 appeared to be associated with more aggressive disease.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Chromosome Aberrations*
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 6*
Chromosomes, Human, Pair 9*
Female
Genetic Markers
Humans
Karyotyping
Leukemia, Myeloid, Acute / etiology
Leukemia, Myeloid, Acute / genetics*
Myelodysplastic Syndromes / complications
Myelodysplastic Syndromes / genetics*

Substances

Genetic Markers