Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

Morphologie. 2019 Mar;103(341):4-10. doi: 10.1016/j.morpho.2018.11.001. Epub 2018 Dec 4.

Abstract

CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management.

Keywords: Assisted reproductive technology; Cystic fibrosis; Epididymis; Mutation; Sertoli cell; Spermatozoa; Testis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator / metabolism
  • Fertility / genetics*
  • Genetic Counseling / methods
  • Humans
  • Infertility, Male / genetics*
  • Infertility, Male / pathology
  • Infertility, Male / therapy
  • Male
  • Mutation
  • Sperm Injections, Intracytoplasmic / methods*
  • Spermatozoa / metabolism
  • Treatment Outcome

Substances

  • CFTR protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator