Association of ATP binding cassette transporter 1 (ABCA 1) gene polymorphism with type 2 diabetes mellitus (T2DM) in Bangladeshi population

Aims: ATP-binding cassette transporter 1 (ABCA1) gene polymorphism has been reported as one of the genetic risk factors for T2DM in various populations with conflicting results. The aim of this study is to investigate the association of ABCA1 C69T polymorphism and lipid profile with T2DM in Bangladeshi population.

Materials and methods: A total of 102 T2DM subjects and 98 healthy controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the PCR-RFLP technique. Serum lipid profiles (total cholesterol, HDL-C, LDL-C and TG) were also estimated by using standard methods.

Results: ABCA 1 (C69T) genotypes frequencies were estimated. The percentages of CC, CT and TT genotypes at 69 position of ABCA1 gene were 31.63%, 58.16% and 10.21% in control as well as 22.54%, 69.60% and 7.86% in diabetes group respectively. Significant association was not found between ABCA1 (C69T) genotypes and T2DM in Bangladeshi population (Odd Ratio: 1.67; 95% Confidence Interval: 0.88 to 3.19 for CT genotype and Odd Ratio: 1.07; Confidence Interval: 0.36 to 3.16 for TT genotype; p > 0.05). Serum lipid profiles were not associated with T2DM.

Conclusion: ABCA1 gene polymorphism might not be a genetic risk factor for T2DM subjects among Bangladeshis. We did not find a relationship between genotypes and lipid concentrations in our two groups. Study with a larger sample size will help us to understand the relationship of ABCA1 C69T genotype and lipid profile with T2DM.