Efficient drug discovery by rational lead hybridization based on crystallographic overlay

Drug Discov Today. 2019 Mar;24(3):805-813. doi: 10.1016/j.drudis.2018.11.021. Epub 2018 Dec 4.

Abstract

In this review, we provide an overview of recent applications of crystallographic overlay-based molecular structure hybridization of lead compounds as a rational strategy for efficient drug discovery, with selected examples, and briefly discuss its advantages compared with other ligand-based methodologies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crystallography
  • Drug Discovery*
  • Humans
  • Molecular Structure