The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans

Wole Akosile; Joanne Voisey; Bruce Lawford; David Colquhounc; Ross McD Young; Divya Mehta

doi:10.1016/j.psychres.2018.10.051

The inflammasome NLRP12 is associated with both depression and coronary artery disease in Vietnam veterans

Psychiatry Res. 2018 Dec:270:775-779. doi: 10.1016/j.psychres.2018.10.051. Epub 2018 Oct 27.

Authors

Wole Akosile¹, Joanne Voisey², Bruce Lawford², David Colquhounc³, Ross McD Young⁴, Divya Mehta⁵

Affiliations

¹ School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia. Electronic address: [email protected].
² School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
³ Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia.
⁴ School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia.
⁵ School of Psychology and Counselling, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.

PMID: 30551324
DOI: 10.1016/j.psychres.2018.10.051

Abstract

Several studies have established that Major depressive disorder is associated with excess inflammation with an elevation of both pro and anti-inflammatory cytokines in major depressive disorder. In addition, individuals with major depressive disorder are at higher risk of developing coronary artery disease. The role of innate immunity and NFκB-mediated inflammation in depression and its increased association with coronary artery disease is yet to be fully elucidated. Polymorphisms in the Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat and Pyrin Domain Containing 12 (NLRP12), are associated with depression and coronary artery disease in trauma exposed individuals. In a cohort of Vietnam War veterans (n = 299) NLRP12 polymorphisms were analysed for association with depression and coronary calcium scores. The NLRP12 polymorphism, rs34436714 was associated with a higher DASS21 Score for depression (p = 0.037). NLRP12 polymorphisms rs34971363 and rs6509825 (p = 0.022 and p = 0.020) were associated with raised coronary calcium score. To our knowledge, this is the first time rs34436714 has been investigated in Vietnam veterans identifying AC as a risk genotype for depression in Caucasian cohorts. It is also the first time the rs34971363 (CG) and rs6509825 (CT) genotype have been associated with raised coronary calcium score.

Keywords: Coronary artery disease; Depression; NLRP12; rs34436714; rs34971363; rs6509825.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Combat Disorders / genetics*
Combat Disorders / immunology
Coronary Artery Disease / genetics*
Coronary Artery Disease / immunology
Depressive Disorder, Major / genetics*
Depressive Disorder, Major / immunology
Genotype*
Humans
Immunity, Innate / genetics
Immunity, Innate / immunology
Inflammasomes / genetics*
Inflammasomes / immunology
Intracellular Signaling Peptides and Proteins / genetics*
Male
NF-kappa B / genetics
Polymorphism, Genetic
Risk Factors
Veterans*

Substances

Inflammasomes
Intracellular Signaling Peptides and Proteins
NF-kappa B
NLRP12 protein, human