The therapeutic potential of curcumin: A review of clinical trials

Bahare Salehi; Zorica Stojanović-Radić; Jelena Matejić; Mehdi Sharifi-Rad; Nanjangud V Anil Kumar; Natália Martins; Javad Sharifi-Rad

doi:10.1016/j.ejmech.2018.12.016

The therapeutic potential of curcumin: A review of clinical trials

Eur J Med Chem. 2019 Feb 1:163:527-545. doi: 10.1016/j.ejmech.2018.12.016. Epub 2018 Dec 7.

Authors

Bahare Salehi¹, Zorica Stojanović-Radić², Jelena Matejić³, Mehdi Sharifi-Rad⁴, Nanjangud V Anil Kumar⁵, Natália Martins⁶, Javad Sharifi-Rad⁷

Affiliations

¹ Bam University of Medical Sciences, Bam, Iran. Electronic address: [email protected].
² Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia. Electronic address: [email protected].
³ Department of Pharmacy, Faculty of Medicine, University of Niš, Boulevard Dr Zorana Đinđića 81, 18000, Niš, Serbia. Electronic address: [email protected].
⁴ Department of Medical Parasitology, Zabol University of Medical Sciences, Zabol, 61663-335, Iran. Electronic address: [email protected].
⁵ Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, 576104, India. Electronic address: [email protected].
⁶ Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, Porto, 4200-319, Portugal; Institute for Research and Innovation in Health (i3S), University of Porto, Porto, 4200-135, Portugal. Electronic address: [email protected].
⁷ Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address: [email protected].

PMID: 30553144
DOI: 10.1016/j.ejmech.2018.12.016

Abstract

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.

Keywords: Clinical trials; Curcuma longa L.; Curcuminoids; Pharmacological effects; Secondary metabolites.

Publication types

Review

MeSH terms

Clinical Trials as Topic*
Curcuma / chemistry
Curcumin / therapeutic use*
Humans
Inflammation / drug therapy
Metabolic Diseases / drug therapy

Substances

Curcumin